Trazodone For Cat Sedation
Trazodone is categorized as a serotonin 2a antagonist/reuptake inhibitor (sari). Injectable sedatives may provide rapid tranquilizing effects but are more difficult to monitor safety at home.
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All of these medications are in gas form.

Trazodone for cat sedation. Use of oral trazodone for sedation in cats: Not many cats will sit still long enough for a mask to be placed over their mouths and noses, and then for the medication to take effect. Trazodone was well tolerated in this population of cats and caused appreciable sedation at all doses.
In contrast, there was a 14% activity increase after placebo. I've taken 150 mg of trazodone before and compared to a 12 pound cat, i'm a huge giant. As of 2012, the approximately 74.1 million cats outnumbered the approximately 69.9 million dogs in this country.
Most cats became profoundly sedated and ataxic (drunken sailor) and serotonin syndrome symptoms including vomiting, diarrhea, seizures, hyperthermia, hypesthesia, depression, mydriasis (wide open pupils), vocalization, blindness, disorientation, and even death have been seen. Cats are not very happy travelers. Sedation is widely used by cat owners when they are going on a trip with their cats.
Administration to cats can be quite challenging. It can be administered at home. Side effects may include sedation, behavior changes, vomiting, and priapism.
The purpose of this study was to evaluate the safety and efficacy of oral trazodone for use as a single dose agent for sedation in cats. 172 172sharescats represent a large part of the us pet population; Further studies are recommended to investigate the use of oral trazodone in cat …
There are different forms of medications used to sedate cats, including: Not as broad an effect as general anesthesia. Benadryl and chlorpheniramine have broad use in cats for sedation and relief of anxiety during travel and grooming.
Trazodone, a serotonin antagonist and reuptake inhibitor, may reduce stress and fear in cats. Trazodone selectively blocks serotonin reuptake, which enhances serotonin’s effects. Trazadone isn't used for cats due the extensive variety of adverse effects in that species.
Accelerometer data showed trazodone 50, 75 and 100 mg caused sedation as measured by activity reduction (83%, 46% and 66%, respectively). In today’s vetgirl online veterinary continuing education blog, we interview dr. Use of oral trazodone for sedation in cats:
4 at higher doses, trazodone acts as a serotonin agonist, and serotonin. So when they are put and locked inside a dark cat carrier and being carried on for a long time it is natural for them to get scared and sometimes it leads to extreme anxiety and stress. Much to my surprise, though a quick search revealed that 100 mg is not an unacceptably high dose.
Trazodone hcl, also known simply as trazodone and by the brand names of oleptro®, desyrel®, is used in dog and cats with behavioral problems or various anxiety related problems including fears and anxiety related to veterinary visits and hospitalization. Patients with heart, kidney, or liver disease or closed angle glaucoma should use this medication with caution. There was a significant reduction in video observation scores when cats were given trazodone 100 mg compared with placebo.
Although these numbers represent an overall decline in dog and cat populations, the proportion of cats that are mature (>7 years old) or geriatric (>11 years old) has. Six laboratory cats were given single 50, 75 and 100 mg. Check out this abstract, published in 2015 in the journal of feline medicine and surgery:
Behavior during examination was not significantly different when cats received trazodone 100 mg compared with placebo. We hypothesized that oral trazodone 1:00 pm, with doses staggered such that each cat received would be well tolerated and would produce mild sedation, medication 90 mins prior to examination.
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